Abstract |
Cell invasion is a nature of malignant gliomas, demeriting to many efforts of the treatment. Matrix metalloproteinase ( MMP) is acknowledged as a key factor in this complicated process. The aim of this study was to investigate whether inhibition of MMP activity in malignant glioma cells could be achieved by a novel agent, BE16627B (BE). Malignant glioma cell lines, U87MG, U251MG, and U373MG, were employed to evaluate inhibitory effect on zymogram, type IV collagenolysis assay, and haptoinvasion assay for 24 h exposure of BE, following preliminar
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Authors | K Watanabe, D Yoshida, M Noha, A Teramoto |
Journal | Journal of neuro-oncology
(J Neurooncol)
Vol. 52
Issue 1
Pg. 1-9
(Mar 2001)
ISSN: 0167-594X [Print] United States |
PMID | 11451198
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Collagen Type IV
- Coloring Agents
- Dipeptides
- Protease Inhibitors
- Succinates
- Tetrazolium Salts
- Thiazoles
- L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- thiazolyl blue
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Topics |
- Antineoplastic Agents
(pharmacology)
- Collagen Type IV
(metabolism)
- Coloring Agents
- Dipeptides
(pharmacology)
- Glioma
(pathology, physiopathology)
- Humans
- Matrix Metalloproteinase 2
(physiology)
- Matrix Metalloproteinase 9
(physiology)
- Neoplasm Invasiveness
- Protease Inhibitors
(pharmacology)
- Succinates
(pharmacology)
- Tetrazolium Salts
- Thiazoles
- Tumor Cells, Cultured
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