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Suppression of matrix metalloproteinase-2 and -9 mediated invasiveness by a novel matrix metalloproteinase inhibitor, BE16627B.

Abstract
Cell invasion is a nature of malignant gliomas, demeriting to many efforts of the treatment. Matrix metalloproteinase (MMP) is acknowledged as a key factor in this complicated process. The aim of this study was to investigate whether inhibition of MMP activity in malignant glioma cells could be achieved by a novel agent, BE16627B (BE). Malignant glioma cell lines, U87MG, U251MG, and U373MG, were employed to evaluate inhibitory effect on zymogram, type IV collagenolysis assay, and haptoinvasion assay for 24 h exposure of BE, following preliminar
AuthorsK Watanabe, D Yoshida, M Noha, A Teramoto
JournalJournal of neuro-oncology (J Neurooncol) Vol. 52 Issue 1 Pg. 1-9 (Mar 2001) ISSN: 0167-594X [Print] United States
PMID11451198 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Collagen Type IV
  • Coloring Agents
  • Dipeptides
  • Protease Inhibitors
  • Succinates
  • Tetrazolium Salts
  • Thiazoles
  • L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9
  • thiazolyl blue
Topics
  • Antineoplastic Agents (pharmacology)
  • Collagen Type IV (metabolism)
  • Coloring Agents
  • Dipeptides (pharmacology)
  • Glioma (pathology, physiopathology)
  • Humans
  • Matrix Metalloproteinase 2 (physiology)
  • Matrix Metalloproteinase 9 (physiology)
  • Neoplasm Invasiveness
  • Protease Inhibitors (pharmacology)
  • Succinates (pharmacology)
  • Tetrazolium Salts
  • Thiazoles
  • Tumor Cells, Cultured

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