Abstract |
Since zinc desferrioxamine ( Zn-DFO) has been shown to be a very potent protector against injuries induced by redox-active metal ions, we examined its protective effect against radiation-induced toxicity. We found that treatment with Zn-DFO given before TBI increased the survival of mice irradiated with 7.5 and 8.5 Gy. Zn-DFO also protected against radiation-induced myelosuppression and body weight loss, while soluble Il6 levels in serum were normalized in mice pretreated with Zn-DFO. We concluded that administration of Zn-DFO prior to TBI protected BALB/c mice from radiation-induced toxicity, increasing survival rates by up to 75%. The biological effect of Zn-DFO is known to result from its effect on the production of intracellular hydroxyl free radicals mediated by redox-active metal ions, and both metal chelation and zinc delivery appear to be equally likely mechanisms for this outcome. We suggest that radiation-induced toxicity is caused by the deleterious effect of redox-active metal ions, and that compounds which modulate this redox activity may act as radioprotectors.
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Authors | R M Nagler, Y Eichen, A Nagler |
Journal | Radiation research
(Radiat Res)
Vol. 156
Issue 2
Pg. 205-9
(Aug 2001)
ISSN: 0033-7587 [Print] United States |
PMID | 11448242
(Publication Type: Journal Article)
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Chemical References |
- Chelating Agents
- Interleukin-6
- Radiation-Protective Agents
- Deferoxamine
- Zinc
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Topics |
- Animals
- Body Weight
(drug effects, radiation effects)
- Bone Marrow
(drug effects, radiation effects)
- Chelating Agents
(pharmacology)
- Deferoxamine
(pharmacology)
- Interleukin-6
(blood)
- Leukocyte Count
- Male
- Mice
- Mice, Inbred BALB C
- Oxidation-Reduction
- Radiation Injuries, Experimental
(blood, pathology, prevention & control)
- Radiation Tolerance
(drug effects)
- Radiation-Protective Agents
(pharmacology)
- Whole-Body Irradiation
- Zinc
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