NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression.

Abstract

NC-1500 is a dihydropyridine type calcium channel blocker. The effect of NC-1500 on mice concanavalin A-induced hepatitis was examined. Treatment of mice with concanavalin A (Con A) caused elevation of plasma transaminase. Pretreatment of mice with NC-1500 (3, 10 and 30 mg/kg, p.o.) prevented this Con A-induced elevation of plasma transaminase. Treatment of mice with Con A induced tumor necrosis factor-alpha (TNF-alpha) mRNA expression in the liver. However, NC-1500 (30 mg/kg, p.o.) did not affect this Con A-induced TNF-alpha mRNA expression in the liver. The present results showed that NC-1500 inhibited Con A-induced hepatitis without affecting TNF-alpha mRNA expression in the liver.

• Authors: T Okamoto, T Kobayashi, S Y Jeong
• Journal: International journal of molecular medicine (Int J Mol Med) Vol. 8 Issue 2 Pg. 181-2 (Aug 2001) ISSN: 1107-3756 [Print] Greece
• PMID: 11445871 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Calcium Channel Blockers
• Dihydropyridines
• Naphthyridines
• RNA, Messenger
• Tumor Necrosis Factor-alpha
• Goe 5438
• Concanavalin A
• Glycyrrhizic Acid
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Aspartate Aminotransferases (blood)
• Calcium Channel Blockers (administration & dosage, pharmacology)
• Chemical and Drug Induced Liver Injury (blood, immunology, prevention & control)
• Concanavalin A (adverse effects)
• Dihydropyridines (administration & dosage, pharmacology)
• Disease Models, Animal
• Female
• Gene Expression (drug effects)
• Glycyrrhizic Acid (pharmacology)
• Mice
• Mice, Inbred BALB C
• Naphthyridines (administration & dosage, pharmacology)
• RNA, Messenger
• Tumor Necrosis Factor-alpha (genetics)