A mutation in Bruton's tyrosine kinase as a cause of selective anti-polysaccharide antibody deficiency.

Abstract	Children and adults can have recurrent infection with invasive encapsulated bacterial pathogens such as Streptococcus pneumoniae as a result of a selective inability to respond to polysaccharide antigens. We have identified a mutation in the gene encoding Bruton's tyrosine kinase in a male patient with selective anti-polysaccharide antibody deficiency.
Authors	P M Wood, A Mayne, H Joyce, C I Smith, D M Granoff, D S Kumararatne
Journal	The Journal of pediatrics (J Pediatr) Vol. 139 Issue 1 Pg. 148-51 (Jul 2001) ISSN: 0022-3476 [Print] United States
PMID	11445810 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Protein-Tyrosine Kinases Agammaglobulinaemia Tyrosine Kinase Btk protein, mouse
Topics	Adult Agammaglobulinaemia Tyrosine Kinase Agammaglobulinemia (genetics, immunology) Animals Antibody Formation Genetic Linkage Humans Male Mice Mice, Inbred CBA Mutation Phenotype Protein-Tyrosine Kinases (genetics) Vaccination X Chromosome

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