Abstract | OBJECTIVES: METHODS: Forty-four patients who had vasculogenic impotence diagnosed on the basis of their sexual history, physical examination, laboratory analysis, polysomnographic recording of nocturnal erections, and dynamic color Doppler sonography of the cavernosal arteries were entered into a randomized, double-blind, placebo-controlled, crossover comparison of a placebo with high-dose isoxsuprine hydrochloride (60 mg/day orally). The treatment consisted of two 30-day courses. After a 14-day washout period, the patients who initially received the placebo for 30 days switched to isoxsuprine hydrochloride for 30 days and vice versa. Erectile function, ejaculation, interest in sex, and physical examination findings were investigated before treatment and at the end of each drug period. RESULTS: Thirty-six patients (82%) completed the entire treatment schedule. Positive clinical results (complete and partial responses) were obtained in 6 men (16.6%) at the end of the isoxsuprine phase and in 7 men (19.4%) after the placebo period. The statistical analysis disclosed no significant difference when isoxsuprine was compared with placebo (P >0.05). Significant drug-related adverse effects occurred in the isoxsuprine group and treatment was discontinued in 2 patients. CONCLUSIONS:
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Authors | M R Safarinejad |
Journal | Urology
(Urology)
Vol. 58
Issue 1
Pg. 95-7
(Jul 2001)
ISSN: 1527-9995 [Electronic] United States |
PMID | 11445487
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Vasodilator Agents
- Isoxsuprine
|
Topics |
- Adult
- Double-Blind Method
- Erectile Dysfunction
(drug therapy)
- Humans
- Hypotension
(chemically induced)
- Impotence, Vasculogenic
(drug therapy)
- Isoxsuprine
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Pain Measurement
(drug effects)
- Treatment Outcome
- Vasodilator Agents
(administration & dosage, adverse effects)
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