[Immunomodulatory properties of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and search for its new derivatives].

Abstract

A strong immunomodulatory effect of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) responsible for the survival of bacteria was shown on isolated macrophages and in experimental infections in mice (typhoid and tularemia). Derivatives of MEC were found by 1H-NMR spectroscopy under stress conditions in colorless mutants of the bacteria and isolated to be subsequently purified and used for modulation of the immune system of animals.

• Authors: V D Potapov, S F Biketov, G R Demina, E I Lysak, G M Titareva, I V Bakhteeva, D N Ostrovskiĭ
• Journal: Prikladnaia biokhimiia i mikrobiologiia (Prikl Biokhim Mikrobiol) 2001 May-Jun Vol. 37 Issue 3 Pg. 274-8 ISSN: 0555-1099 [Print] Russia (Federation)
• Vernacular Title: Immunomoduliatornye svoĭstva i poisk novykh proizvodnykh 2-C-Metil-D-éritriol-2,4-tsiklopirofosfata.
• PMID: 11443893 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• 2-methyl-butan-1,2,3,4-tetraol-2,4-cyclopyrophosphate
• Erythritol

Topics

• Adjuvants, Immunologic (chemistry, pharmacology)
• Animals
• Corynebacterium
• Erythritol (analogs & derivatives, chemistry, pharmacology)
• Macrophages, Peritoneal (drug effects, immunology)
• Mice
• Mice, Inbred BALB C
• Phagocytosis (drug effects)
• Tularemia (immunology)
• Typhoid Fever (immunology)