Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

Abstract	The integrin alphavbeta6 is a fibronectin receptor whose expression is not detectable on normal oral epithelium but is increased significantly in healing and in oral epithelial dysplasia and oral squamous cell carcinoma, suggesting it may promote changes associated with tumor development. To study whether alphavbeta6 may drive invasive behavior we have used transfection and retroviral infection to create a panel of epithelial cell lines expressing various levels of alphavbeta6. We report that increased expression of alphavbeta6 in malignant keratinocytes promotes invasion and leads to an increased capacity for migration towards fibronectin. alphavbeta6 expression may have a significant role in contributing to the malignant behavior of epithelial cells.
Authors	G J Thomas, M P Lewis, S A Whawell, A Russell, D Sheppard, I R Hart, P M Speight, J F Marshall
Journal	The Journal of investigative dermatology (J Invest Dermatol) Vol. 117 Issue 1 Pg. 67-73 (Jul 2001) ISSN: 0022-202X [Print] United States
PMID	11442751 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antigens, Neoplasm Biocompatible Materials Drug Combinations Fibronectins Integrins Laminin Plastics Proteoglycans Receptors, Fibronectin integrin alphavbeta6 matrigel Collagen
Topics	Antigens, Neoplasm Biocompatible Materials Carcinoma, Squamous Cell (pathology, physiopathology) Cell Adhesion (physiology) Cell Division (physiology) Cell Movement (drug effects, physiology) Collagen Drug Combinations Fibronectins (metabolism, pharmacology) Focal Adhesions (chemistry) Gene Expression Regulation, Neoplastic Humans Integrins (analysis, genetics, metabolism) Keratinocytes (metabolism, pathology) Laminin Mouth Neoplasms (pathology, physiopathology) Neoplasm Invasiveness (pathology, physiopathology) Plastics Proteoglycans Receptors, Fibronectin (analysis, metabolism) Retroviridae (genetics) Skin Neoplasms (pathology, physiopathology) Transfection Tumor Cells, Cultured

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