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[Risk factors for nosocomial sepsis: a case-control study].

AbstractBACKGROUND:
The objective of this study was to identify the risk factors associated with the nosocomial sepsis syndrome according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference.
PATIENTS AND METHOD:
A 1-year prospective case-control study matched for sex, age (+/- 5 years), and pre-infection hospital stay (+/- 1 day) was performed in a 1,200-bed university hospital. Cases were selected according to the above criteria. Controls were randomly selected from the daily list of hospitalized patients. Crude and adjusted odds ratios (OR) were determined.
RESULTS:
346 cases and 346 controls were included. Multivariate analysis identified the following intrinsic risk factors: coma in the 48 hours before sepsis (OR: 15.1; CI 95%, 5.6-41.2), renal failure (OR: 3.4; CI 95%; 1.5-10.8), neoplasm (OR: 2.4; CI 95%, 1.1-5.1), prosthesis material (OR: 2.7; CI 95%, 1.0-7.8), and serum albumin concentration at admission lower than 3.1 g/dl (OR: 5.3; CI 95%, 2.3-12.4). Main extrinsic risk factors were: previous nosocomial infection (OR: 12.5; CI 95%, 1.61-96.3), intensive care unit (ICU) stay (OR: 10.6; CI 95%, 3.1-36.2), naso-gastric tube (OR: 8.4; CI 95%, 2.3-31.3), indwelling urinary catheter (OR: 5.0; CI 95%, 1.4-18.9), H2 blockers treatment (OR: 5.0; CI 95%, 1.6-15.2), and IV central line (OR: 4.1; CI 95%, 1.2-14.0).
CONCLUSION:
In our study, main risk factors for development of nosocomial sepsis were presence of coma in the 48 hours before sepsis, ICU stay, and prior cross infection during hospitalization.
AuthorsC Fariñas Alvarez, M Carmen Fariñas, J Llorca, M Delgado Rodríguez
JournalMedicina clinica (Med Clin (Barc)) Vol. 116 Issue 20 Pg. 765-9 (Jun 02 2001) ISSN: 0025-7753 [Print] Spain
Vernacular TitleFactores de riesgo de sepsis nosocomial: un estudio de casos y controles.
PMID11440680 (Publication Type: English Abstract, Journal Article)
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Confidence Intervals
  • Cross Infection (etiology, microbiology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Prospective Studies
  • Risk Factors
  • Sepsis (etiology, microbiology)

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