Histone acetylation and disease.

Abstract	Differential acetylation of histones and transcription factors plays an important regulatory role in developmental processes, proliferation and differentiation. Aberrant acetylation or deacetylation leads to such diverse disorders as leukemia, epithelial cancers, fragile X syndrome and Rubinstein-Taybi syndrome. The various groups of histone acetyltransferases (CBP/p300, GNAT, MYST, nuclear receptor coactivators and TAFII250) and histone deacetylases are surveyed with regard to their possible or known involvement in cancer progression and human developmental disorders. Current treatment strategies are discussed, which are still mostly limited to histone deacetylase inhibitors such as trichostatin A and butyrate.
Authors	S Timmermann, H Lehrmann, A Polesskaya, A Harel-Bellan
Journal	Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 58 Issue 5-6 Pg. 728-36 (May 2001) ISSN: 1420-682X [Print] Switzerland
PMID	11437234 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	DNA-Binding Proteins Histone Deacetylase Inhibitors Histones Nuclear Proteins Receptors, Cytoplasmic and Nuclear Saccharomyces cerevisiae Proteins TATA-Binding Protein Associated Factors Trans-Activators Transcription Factor TFIID Acetyltransferases Histone Acetyltransferases KAT7 protein, human KAT8 protein, human TATA-binding protein associated factor 250 kDa Histone Deacetylases
Topics	Acetylation Acetyltransferases (metabolism) Animals Cell Cycle Cell Differentiation DNA-Binding Proteins (metabolism) Disease Fragile X Syndrome (genetics) Gene Expression Regulation, Developmental Gene Silencing Histone Acetyltransferases Histone Deacetylase Inhibitors Histone Deacetylases (metabolism) Histones (chemistry, metabolism) Humans Neoplasms (drug therapy, genetics) Nuclear Proteins (metabolism) Receptors, Cytoplasmic and Nuclear (metabolism) Saccharomyces cerevisiae Proteins TATA-Binding Protein Associated Factors Trans-Activators (metabolism) Transcription Factor TFIID Translocation, Genetic (genetics)

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