HCFU (
carmofur;
Mifurol) is an
5-FU analog. The maximum blood concentration of
HCFU in
HCFU fraction (Cmax) after gastric resection was higher than before resection. Hot sensation and pollakiuria, characteristic side effects of
HCFU, are dependent on concentration of
HCFU fraction in blood. Therefore, it is considered that the frequency of occurrence of side effects after gastric resection is high. For that reason, we thought that if absorption of
HCFU could be reduced, fewer side effects would result. We focused on the fact that drugs which include
aluminium gel may decrease absorption in combined drugs, and thought it would be possible to delay absorption in
HCFU by using them. We studied the
HCFU concentration in the
HCFU fraction and
5-FU concentration in blood, respectively, in two cases: 1) single
oral administration of
HCFU 100 mg and 2) coadministration with hydroxyaluminium gel (ALG) 10 ml in the whole or partial resection of
gastric cancers for 8 patients. We found that the concentration of
HCFU in the
HCFU fraction 2 hours after its administration decreased significantly: 3.24 +/- 1.78 (single administration), 1.37 +/- 0.91 (coadministration with ALG) (p = 0.023).
HCFU concentration in the
HCFU fraction seemed to decrease for coadministration with ALG in the area under the time-blood concentration curve (AUG) (p = 0.071). The 5-FU concentration did not seem to decrease in either case. From these results, the coadministration of
HCFU with ALG seems to be effective for the inhibition of
adverse drug reaction after the resection of
gastric cancers.