Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury.

Abstract

OBJECTIVE:

To evaluate the effects of PFC aerosol compared to PGI2 aerosol and NaCl aerosol on gas exchange and lung mechanics in oleic acid-induced acute lung injury.

DESIGN:

A prospective, controlled, randomised, in vivo animal laboratory study.

SETTING:

Research laboratory at an university hospital.

SUBJECTS:

Twenty one (n = 21) adult sheep of either gender weighing 26.8+/-6.4 kg.

INTERVENTIONS:

The animals were randomised to three groups: PFC aerosol (perfluorooctane), PFC group; prostacyclin aerosol (Flolan), PGI2 group; and NaCl aerosol (0.9% sodium chloride solution), control group. After induction of anaesthesia and placement of vascular catheters, lung injury was induced with 0.12 ml x kg(-1) oleic acid. Aerosols were continuously administered for 2 h using a jet nebuliser. Gas exchange, pulmonary mechanic, and haemodynamic parameters were obtained at regular intervals.

MEASUREMENTS AND MAIN RESULTS:

PFC aerosol increased oxygenation (PaO2) 15 min after the initiation of treatment up to 120 min (P < 0.05). Transpulmonary shunt improved in the PFC group (P < 0.05) while it did not change in the two other groups. PFC aerosol reduced maximum airway pressure (Pmax) (median) significantly from (median) 38 mbar to 32 mbar (P < 0.05). Static compliance improved significantly in the PFC group (P < 0.05).

CONCLUSION:

The inhalation of a PFC aerosol led to a significant improvement in pulmonary mechanics and gas exchange, which was not observed in the other two groups. These data suggest that a small dose of perfluorocarbon will have beneficial effects on gas exchange and respiratory mechanics. Therefore, the non-invasive aerosol application technique seems to be a reasonable alternative to administer perfluorocarbons in severe lung injury.

• Authors: M Ragaller, J Bleyl, U Tschö, T Winkler, M Regner, S Rasche, T Koch, M Albrecht
• Journal: Intensive care medicine (Intensive Care Med) Vol. 27 Issue 5 Pg. 889-97 (May 2001) ISSN: 0342-4642 [Print] United States
• PMID: 11430546 (Publication Type: Journal Article)

Chemical References

• Aerosols
• Fluorocarbons
• Oleic Acid
• perfluorooctane
• Epoprostenol

Topics

• Aerosols (administration & dosage)
• Animals
• Disease Models, Animal
• Drug Delivery Systems
• Epoprostenol (administration & dosage)
• Female
• Fluorocarbons (administration & dosage)
• Hemodynamics (drug effects)
• Male
• Oleic Acid
• Positive-Pressure Respiration
• Pulmonary Gas Exchange (drug effects)
• Respiratory Distress Syndrome (chemically induced, physiopathology, therapy)
• Sheep