Postprandial hyperlipidemia in Zucker diabetic fatty fa/fa rats, an animal model of type II diabetes, and its amelioration by acyl-CoA:cholesterol acyltransferase inhibition.

Abstract

Postprandial hyperlipidemia (PH) is frequently observed in diabetic patients. We performed an oral fat-loading test in Zucker diabetic fatty (ZDF) fa/fa rats, a model for type II diabetes, to determine whether PH was induced in the rats. Post fat-loading changes in serum cholesterol and triglyceride levels were significantly greater in the fa/fa rats than those seen in their lean littermates and an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor significantly reduced these levels by 24% and 31%, respectively. Therefore, we confirmed that PH appeared in ZDF fa/fa rats by fat loading and ACAT inhibition may be a potential treatment for PH.

• Authors: K Fujinami, K Kojima, K Aragane, J Kusunoki
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 86 Issue 1 Pg. 127-9 (May 2001) ISSN: 0021-5198 [Print] Japan
• PMID: 11430465 (Publication Type: Journal Article)

Chemical References

• Anticholesteremic Agents
• Blood Glucose
• Dietary Fats
• Triglycerides
• Cholesterol
• Sterol O-Acyltransferase

Topics

• Animals
• Anticholesteremic Agents (pharmacology)
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• Cholesterol (blood)
• Diabetes Mellitus, Type 2 (blood, genetics, metabolism)
• Dietary Fats (pharmacokinetics)
• Hyperlipidemias (blood)
• Postprandial Period (physiology)
• Rats
• Rats, Zucker
• Sterol O-Acyltransferase (antagonists & inhibitors)
• Triglycerides (blood)