Abstract |
A detailed analysis of the toxic composition in the hepatopancreas of mussels from northern Adriatic sea has been performed. Along with some polyether toxins of DSP ( diarrhetic shellfish poisoning) type, such as yessotoxin and its analogues, which are responsible for a variety of human seafood poisonings throughout the world, we have now isolated a new type of toxin, the chlorosulfolipid 1, which is completely different in structure from the polyether DSP-toxins isolated so far. The structural determination of the new toxin, including its absolute stereochemistry, has been performed by extensive NMR analysis and molecular mechanics and dynamics calculations.
|
Authors | P Ciminiello, E Fattorusso, M Forino, M Di Rosa, A Ianaro, R Poletti |
Journal | The Journal of organic chemistry
(J Org Chem)
Vol. 66
Issue 2
Pg. 578-82
(Jan 26 2001)
ISSN: 0022-3263 [Print] United States |
PMID | 11429832
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Animals
- Bivalvia
(chemistry)
- Cell Line
- Cell Survival
(drug effects)
- Digestive System
(chemistry)
- Foodborne Diseases
(etiology)
- Humans
- Lipids
(chemistry, isolation & purification, toxicity)
- Marine Toxins
(chemistry, isolation & purification)
- Seawater
- Shellfish
|