[Pemphigoid gestationis: treatment by topical class I corticosteroid].

Abstract

BACKGROUND:

Systemic corticosteroid is the main treatment of severe forms of pemphigoid gestationis. We report a case of generalised pemphigoid gestationis successfully treated with very potent topical corticosteroid.

CASE:

A 37-year-old woman developed during her third pregnancy with a new partner an urticated generalised eruption associated with bullous lesions. The diagnosis of pemphigoid gestationis was confirmed by direct immunofluorescence which detected a linear C3 deposition along the basement membrane zone and the positivity of Herpes Gestationis Factor (10 units). Local treatment with potent corticosteroid (betamethasone dipropionate 0.05 p. 100) failed and the patient was successfully treated by clobetasol propionate 0.05 p. 100 cream. The infant, in good health, was not delivered prematurely.

DISCUSSION:

Severe form of pemphigoid gestationis are currently treated with 0.5 to 1 mg/kg/day of systemic corticosteroids, with maternal and pediatric possible side effects. As in bullous pemphigoid, this observation underlines the efficiency and good tolerance of very potent corticosteroid in severe forms of pemphigoid gestationis.

• Authors: L Valeyrie, B Lebrun-Vignes, N Bodak, M Grossin, V Descamps, B Crickx, S Bélaïch
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 128 Issue 5 Pg. 638-40 (May 2001) ISSN: 0151-9638 [Print] France
• Vernacular Title: Pemphigoïde de la grossesse: traitement par corticothérapie locale de classe I.
• PMID: 11427799 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Glucocorticoids
• betamethasone-17,21-dipropionate
• Betamethasone
• Clobetasol

Topics

• Administration, Cutaneous
• Adult
• Anti-Inflammatory Agents (classification, therapeutic use)
• Betamethasone (analogs & derivatives, classification, therapeutic use)
• Clobetasol (analogs & derivatives, classification, therapeutic use)
• Female
• Fluorescent Antibody Technique, Direct
• Glucocorticoids
• Humans
• Pemphigoid, Bullous (drug therapy, pathology)
• Pregnancy
• Pregnancy Complications (drug therapy, pathology)
• Pregnancy Outcome
• Treatment Outcome