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Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis.

Abstract
Previously, we showed that vaccination with the glycoprotein D (gD) gene of pseudorabies virus (PrV) delivered by Escherichia coli induced protective immune responses. In this study, we report that oral DNA vaccination with attenuated Salmonella choleraesuis carrying the PrV gD gene conferred protective immunity in mice against PrV. Moreover, co-delivery of the prothymosin alpha gene carried by S. choleraesuis enhanced the vaccine efficacy. Our results thus demonstrate for the first time, to our knowledge, the effectiveness of oral DNA vaccination using S. choleraesuis as a delivery vehicle and the potential usefulness of prothymosin alpha as a DNA vaccine adjuvant.
AuthorsA L Shiau, Y L Chen, C Y Liao, Y S Huang, C L Wu
JournalVaccine (Vaccine) Vol. 19 Issue 28-29 Pg. 3947-56 (Jul 16 2001) ISSN: 0264-410X [Print] Netherlands
PMID11427270 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Antibodies, Bacterial
  • Antibodies, Viral
  • Protein Precursors
  • Pseudorabies Vaccines
  • Vaccines, DNA
  • Viral Envelope Proteins
  • glycoprotein D, pseudorabies virus
  • prothymosin alpha
  • Thymosin
Topics
  • Adjuvants, Immunologic (administration & dosage, genetics)
  • Administration, Oral
  • Animals
  • Antibodies, Bacterial (biosynthesis)
  • Antibodies, Viral (biosynthesis)
  • Female
  • Genetic Vectors
  • Herpesvirus 1, Suid (genetics, immunology)
  • In Vitro Techniques
  • Lac Operon
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Plasmids (genetics)
  • Promoter Regions, Genetic
  • Protein Precursors (administration & dosage, genetics)
  • Pseudorabies (immunology, prevention & control)
  • Pseudorabies Vaccines (administration & dosage, genetics)
  • Salmonella (genetics, immunology)
  • T-Lymphocytes, Cytotoxic (immunology)
  • Thymosin (administration & dosage, analogs & derivatives, genetics)
  • Vaccines, DNA (administration & dosage, genetics)
  • Viral Envelope Proteins (genetics, immunology)

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