Abstract | BACKGROUND: METHODS: The objective was to reinvestigate 27 patients with collagenous colitis > or = 3 years after index investigation. The clinical course was evaluated by means of an interview, a review of the hospital records and registration of symptoms over a period of 7 days. The patients were invited to undergo a repeat colonoscopy and 75SeHCAT measurement. Initial and follow-up data and 75SeHCAT values from 29 controls were compared. RESULTS: The median follow-up time was 4.2 (range 3-5.3) years. Twenty-two patients underwent a repeat 75SeHCAT test, 23 patients a colonoscopy and in 25 patients the clinical course could be evaluated. The 75SeHCAT values were abnormal in 32% at follow-up versus 44% at index, and the median retention value was 19% (range 2-69) versus 12% (range 0.5-41) (P = 0.024) although lower than in the control groups figure of 38% (range 8-91) (P < 0.005). Histopathology had improved independently of bile acid malabsorption, gender, smoking and autoimmune disease at follow-up. Four were normalized. Patients on bile acid binders had no significant change of histopathology. Four patients had recovered, seven displayed an intermittent course and 14 had continuous diarrhoea. CONCLUSIONS:
Collagenous colitis and bile acid malabsorption seem to be associated yet independent disorders. The histopathology improves during the long-term course although only a few patients resolve.
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Authors | K A Ung, A Kilander, O Nilsson, H Abrahamsson |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 36
Issue 6
Pg. 601-9
(Jun 2001)
ISSN: 0036-5521 [Print] England |
PMID | 11424318
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bile Acids and Salts
- Selenium Radioisotopes
- Cholestyramine Resin
- Taurocholic Acid
- 23-seleno-25-homotaurocholic acid
|
Topics |
- Bile Acids and Salts
(metabolism)
- Cholestyramine Resin
(therapeutic use)
- Colitis
(metabolism, pathology)
- Colon
(pathology)
- Colonoscopy
- Female
- Follow-Up Studies
- Humans
- Ileum
(pathology)
- Malabsorption Syndromes
(drug therapy, metabolism, pathology)
- Male
- Middle Aged
- Selenium Radioisotopes
- Taurocholic Acid
(analogs & derivatives)
- Time Factors
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