Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae-like cyst formation.

Abstract	We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae-like cystic change. A 53-year-old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bullae, a subsequent extirpation of the pulmonary nodules was performed, and a pathological examination showed multiple leiomyomatous nodules with occasional cystic change. A review of the previous slides of the uterus and immunohistochemical analysis of the proliferating ability using anti-Ki-67 and anti-proliferating cell nuclear antigen (PCNA) antibodies were performed. Proliferating cells of the uterus had very few mitotic figures for their high cellularity, and the labeling indices of Ki-67 and PCNA indicated very low levels in both uterine neoplasm and pulmonary nodules. From these findings, an intravenous leiomyomatosis associated with multiple pulmonary metastases was diagnosed.
Authors	K Matsumoto, T Yamamoto, T Hisayoshi, G Asano
Journal	Pathology international (Pathol Int) Vol. 51 Issue 5 Pg. 396-401 (May 2001) ISSN: 1320-5463 [Print] Australia
PMID	11422800 (Publication Type: Case Reports, Journal Article)
Chemical References	Actins Apoproteins Ki-67 Antigen Mucin-1 Proliferating Cell Nuclear Antigen Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants Receptors, Estrogen Receptors, Progesterone pulmonary surfactant apoprotein
Topics	Actins (analysis) Apoproteins (analysis) Cysts (pathology) Female Humans Ki-67 Antigen (analysis) Leiomyomatosis (chemistry, diagnostic imaging, pathology, surgery) Lung Neoplasms (chemistry, diagnostic imaging, secondary, surgery) Middle Aged Mucin-1 (analysis) Neoplasm Invasiveness Proliferating Cell Nuclear Antigen (analysis) Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants (analysis) Radiography, Thoracic Receptors, Estrogen (analysis) Receptors, Progesterone Tomography, X-Ray Computed Uterine Neoplasms (chemistry, diagnostic imaging, pathology, surgery) Uterus (blood supply, pathology)

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