Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family.

Abstract

A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining alpha1 globin gene on a chromosome 16 containing the (-alpha 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.

• Authors: K F Leung, W Y Au, A Y Chan, L C Chan, J S Waye, D H Chui, S K Ma
• Journal: Clinical and laboratory haematology (Clin Lab Haematol) Vol. 23 Issue 1 Pg. 53-5 (Feb 2001) ISSN: 0141-9854 [Print] England
• PMID: 11422231 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hemoglobins, Abnormal
• hemoglobin Q Thailand

Topics

• Adult
• Anemia, Hemolytic, Congenital (etiology, genetics)
• China
• Family Health
• Female
• Genotype
• Hemoglobins, Abnormal (genetics)
• Heterozygote
• Humans
• Nuclear Family
• Osmotic Fragility (genetics)
• Pedigree
• Phenotype
• Spherocytosis, Hereditary (blood, complications, genetics)