Treatment of migraine attacks with intranasal alniditan: an open study.
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| Abstract |
In this open phase-II clinical tolerability trial 17 neurologists enrolled a total of 112 patients and instructed them to administer a maximum of two doses of intranasal alniditan, a 5-HT1B/D receptor agonist, for the treatment of three consecutive migraine attacks of moderate to severe intensity. A second dose of the trial medication was allowed within 1-24 h after the first administration. At 1 h after intranasal administration, 70/103 (68%) patients had responded to treatment (reduction from severe or moderate headache before treatment to mild or no headache) after their first migraine attack, 65/94 (69%) after their second and 52/75 (71%) after their third. In 187/270 (69%) of all attacks, patients were considered responders at 1 h. The median time to onset of effect was 30 min. The migraine headache recurred in 44% (attack 1), 55% (attack 2) and 44% (attack 3) after 4-5 h. Sixty-eight per cent of the patients reported nasal irritation, 19% taste disturbance and 44% throat irritation. Alniditan 2 mg, administered via the intranasal route, was effective in relieving migraine headaches in over two-thirds of the patients at 1 h.
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| Authors | H C Diener, P Louis, R Schellens, F De Beukelaar, Study Group |
| Journal | Cephalalgia : an international journal of headache (Cephalalgia) Vol. 21 Issue 2 Pg. 140-4 (Mar 2001) ISSN: 0333-1024 [Print] England |
| PMID | 11422097 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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