New sesquiterpene hydroquinones from a Taiwanese marine sponge, Hippospongia metachromia.

Abstract

In addition to metachromins A (1), B (2), and E (9), two new sesquiterpene hydroquinones, hippochromins A and B (3, 4), were isolated from the Taiwanese marine sponge Hippospongia metachromia. The structures of 4--6 were established by extensive 2D NMR analysis. Metachromins A (1) and B (2), hippochromin A diacetate (5), and metachromin B monoacetate (8) exhibited potent cytotoxicities against human colon (COLO-205) and nasopharyngeal (KB) tumor cells, while compounds 6, 7, and 9 were inactive.

• Authors: Y C Shen, C Y Chen, Y H Kuo
• Journal: Journal of natural products (J Nat Prod) Vol. 64 Issue 6 Pg. 801-3 (Jun 2001) ISSN: 0163-3864 [Print] United States
• PMID: 11421749 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Quinones
• Sesquiterpenes
• metachromin A
• metachromin B
• metachromin E

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Magnetic Resonance Spectroscopy
• Porifera (chemistry)
• Quinones (chemistry, pharmacology)
• Sesquiterpenes (chemistry, pharmacology)
• Spectrometry, Mass, Fast Atom Bombardment
• Spectrophotometry, Infrared
• Spectrophotometry, Ultraviolet
• Taiwan
• Tumor Cells, Cultured