Chemical constituents from Lippia sidoides and cytotoxic activity.

Abstract

Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone (13), were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3--13 were evaluated against HL60, SW1573, and CEM cell lines. Only tectol (6) and lippsidoquinone (13) exhibited significant activity against human leukemia cell lines HL60 and CEM.

• Authors: S M Costa, T L Lemos, O D Pessoa, C Pessoa, R C Montenegro, R Braz-Filho
• Journal: Journal of natural products (J Nat Prod) Vol. 64 Issue 6 Pg. 792-5 (Jun 2001) ISSN: 0163-3864 [Print] United States
• PMID: 11421746 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Insecticides
• Molluscacides
• Naphthoquinones
• lippsidoquinone

Topics

• Aedes
• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Biomphalaria
• Brazil
• Drug Screening Assays, Antitumor
• Insecticides (chemistry, isolation & purification, toxicity)
• Magnetic Resonance Spectroscopy
• Molluscacides (chemistry, isolation & purification, toxicity)
• Naphthoquinones (chemistry, pharmacology)
• Plants, Medicinal (chemistry)
• Spectrophotometry, Infrared
• Tumor Cells, Cultured