| Abstract | The efficacy and field safety of marbofloxacin (Zeniquin) for the treatment of superficial and deep bacterial pyoderma were evaluated. Seventy-two dogs were treated with 2.75 mg kg-1 of marbofloxacin orally once daily for 21 or 28 days. Sixty-two dogs (86%) had superficial pyoderma and 10 (14%) had deep pyoderma. A history of prior pyoderma was reported in 39/72 dogs. Pretreatment aerobic bacteriologic cultures of skin lesions were performed in 47 cases and the predominant pathogen isolated was Staphylococcus intermedius. Treatment was successful in 62/72 (86.1%) dogs, improvement was noted in 6/72 (8.3%) dogs and treatment failed in 4/72 (5.6%) dogs. Adverse effects associated with treatment included listlessness, anorexia, vomiting, soft stool, flatulence and polydipsia; these adverse effects were seen in only 6/81 dogs. Marbofloxacin was safe and effective for the treatment of superficial and deep pyoderma in dogs at the dosage used in this study. |
| Authors | M Paradis, L Abbey, B Baker, M Coyne, M Hannigan, D Joffe, B Pukay, A Trettien, S Waisglass, J Wellington
(Affiliation: Department of Clinical Sciences, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, St-Hyacinthe, Québec, Canada, J2S 7C6. paradima at medvet.umontreal.ca)
|
| Journal | Veterinary dermatology
(Vet Dermatol)
Vol. 12
Issue 3
Pg. 163-9
(Jun 2001)
ISSN: 0959-4493 England |
| PMID | 11420932
(Publication Type: Evaluation Studies, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Infective Agents
- Fluoroquinolones
- Quinolones
- marbofloxacin
|
| Topics |
- Administration, Oral
- Animals
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Breeding
- Canada
- Dog Diseases
(drug therapy)
- Dogs
- Female
- Fluoroquinolones
- Male
- Pyoderma
(drug therapy, veterinary)
- Quinolones
(administration & dosage, therapeutic use)
- Severity of Illness Index
- Staphylococcal Infections
(drug therapy, veterinary)
- Treatment Outcome
|
