Response of refractory Kawasaki disease to pulse steroid and cyclosporin A therapy.

Abstract

We describe a child with aggressive and protracted Kawasaki disease with coronary aneurysms, myocarditis, pericarditis and valvular insufficiency, despite repeated administration of intravenous immunoglobulin. After a transient response to pulse corticosteroids, his disease ultimately subsided with combination therapy with pulse and high dosage corticosteroids and cyclosporin A. Aggressive immunosuppressive therapy with high dosage corticosteroids and cyclosporin A may be beneficial in patients with refractory Kawasaki disease.

• Authors: V Raman, J Kim, A Sharkey, T Chatila
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 20 Issue 6 Pg. 635-7 (Jun 2001) ISSN: 0891-3668 [Print] United States
• PMID: 11419513 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Immunoglobulins, Intravenous
• Immunosuppressive Agents
• Cyclosporine
• Aspirin
• Methylprednisolone

Topics

• Anti-Inflammatory Agents (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Aspirin (therapeutic use)
• Child, Preschool
• Cyclosporine (therapeutic use)
• Drug Therapy, Combination
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Immunosuppressive Agents (therapeutic use)
• Male
• Methylprednisolone (therapeutic use)
• Mucocutaneous Lymph Node Syndrome (drug therapy, immunology)
• Recurrence