[Effects of bacterial extract IRS-19 on the concentration of hydrogen peroxide and myeloperoxidase activity in nasal washings of patients with chronic bronchitis].

Abstract

AIM:

To determine the effect of intranasal treatment with IRS-19, an immunomodulating agent, on the number of polymorphonuclear leukocytes (PMNL), H2O2 concentration and myeloperoxidase (MPO) activity in nasal washings.

MATERIAL AND METHODS:

28 adult patients of both sexes with chronic bronchitis participated in an open study of intranasal treatment with IRS-19.

RESULTS:

The number of PMNL recovered from nasal spaces increased from 4460 +/- 3960 to 10,490 +/- 10,950 cells/ml (p < 0.02) after two month administration of IRS-19. It was accompanied by 2.6- and 1.4-fold increase (p < 0.001) in MPO activity and H2O2 concentration, respectively. However, no correlation was found between increments in these three variables.

CONCLUSION:

Since PMNL and MPO--H2O2--Cl- system are involved in the first line of defense against invading pathogens it is suggested that the above mentioned changes may represent one among mechanisms leading to enhancement of antibacterial defence in the airways in response to treatment with IRS-19.

• Authors: D Nowak, M Prozynski, T Pietras, R Stolarek, P Mazerant, M Leder
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 73 Issue 3 Pg. 40-4 ( 2001) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie bakterial'nogo ékstrakta IRS-19 na kontsentratsiiu perekisi vodoroda i aktivnost' mieloperoksidazy v smyvakh iz polosti nosa u bol'nykh khronicheskim bronkhitom.
• PMID: 11417179 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• IRS 19
• Hydrogen Peroxide
• Peroxidase

Topics

• Adjuvants, Immunologic (pharmacology, therapeutic use)
• Adult
• Bacteria
• Bronchitis (drug therapy, immunology)
• Chronic Disease
• Female
• Humans
• Hydrogen Peroxide (analysis)
• Leukocyte Count
• Male
• Middle Aged
• Neutrophils (drug effects, immunology)
• Peroxidase (analysis)
• Spectrometry, Fluorescence