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Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate.

Abstract
The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.
AuthorsJ A Castro Hermida, M E Ares-Mazás, L Nieto Reyes, F Otero Espinar, J Blanco Méndez
JournalParasitology research (Parasitol Res) Vol. 87 Issue 6 Pg. 449-52 (Jun 2001) ISSN: 0932-0113 [Print] Germany
PMID11411943 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amebicides
  • Cyclodextrins
  • Drug Carriers
  • Excipients
  • Furans
  • beta-Cyclodextrins
  • betadex
  • diloxanide furoate
Topics
  • Amebicides (therapeutic use)
  • Animals
  • Cattle
  • Cryptosporidiosis (drug therapy, parasitology)
  • Cryptosporidium parvum (isolation & purification, physiology)
  • Cyclodextrins (therapeutic use)
  • Disease Models, Animal
  • Drug Carriers
  • Drug Therapy, Combination
  • Excipients
  • Furans (therapeutic use)
  • Mice
  • Parasite Egg Count
  • beta-Cyclodextrins

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