Abstract |
The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.
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Authors | J A Castro Hermida, M E Ares-Mazás, L Nieto Reyes, F Otero Espinar, J Blanco Méndez |
Journal | Parasitology research
(Parasitol Res)
Vol. 87
Issue 6
Pg. 449-52
(Jun 2001)
ISSN: 0932-0113 [Print] Germany |
PMID | 11411943
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amebicides
- Cyclodextrins
- Drug Carriers
- Excipients
- Furans
- beta-Cyclodextrins
- betadex
- diloxanide furoate
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Topics |
- Amebicides
(therapeutic use)
- Animals
- Cattle
- Cryptosporidiosis
(drug therapy, parasitology)
- Cryptosporidium parvum
(isolation & purification, physiology)
- Cyclodextrins
(therapeutic use)
- Disease Models, Animal
- Drug Carriers
- Drug Therapy, Combination
- Excipients
- Furans
(therapeutic use)
- Mice
- Parasite Egg Count
- beta-Cyclodextrins
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