Abstract |
Restenosis from neointimal proliferation is a frequent complication of intracoronary stenting and catheter-based revascularization procedures. Currently, there is no known therapeutic strategy that has been sufficiently effective to warrant its widespread use. In the present study, the anti-proliferative properties of a matrix ( collagen)-targeted retroviral vector bearing a mutant cyclin G1 (DNT 41-249) construct was evaluated in vitro and in vivo. In controlled one-month efficacy studies, the intraluminal instillation of the mutant cyclin G1 vector significantly inhibited neointima lesion formation in balloon-injured rat arteries without neointimal growth, associated necrosis or intense inflammatory reaction. Taken together, these data extend the potential utility of the matrix-targeted mutant cyclin G1 retroviral vector for management of vascular restenosis.
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Authors | F Xu, M F Prescott, P X Liu, Z H Chen, G Liau, E M Gordon, F L Hall |
Journal | International journal of molecular medicine
(Int J Mol Med)
Vol. 8
Issue 1
Pg. 19-30
(Jul 2001)
ISSN: 1107-3756 [Print] Greece |
PMID | 11408944
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCNG1 protein, human
- Ccng1 protein, mouse
- Ccng1 protein, rat
- Cyclin G
- Cyclin G1
- Cyclins
- DNA, Antisense
- DNA, Recombinant
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Topics |
- 3T3 Cells
- Amino Acid Sequence
- Angioplasty, Balloon
(adverse effects)
- Animals
- Carotid Arteries
(chemistry, pathology)
- Carotid Artery Injuries
(etiology, genetics, prevention & control)
- Cell Division
(drug effects, genetics)
- Cell Line
- Cyclin G
- Cyclin G1
- Cyclins
(administration & dosage, analysis, genetics, therapeutic use)
- DNA, Antisense
(genetics)
- DNA, Recombinant
(genetics)
- Gene Transfer Techniques
- Genetic Therapy
(methods)
- Genetic Vectors
(administration & dosage)
- Humans
- Immunohistochemistry
- Mice
- Molecular Sequence Data
- Muscle, Smooth, Vascular
(cytology, drug effects, metabolism)
- Mutation
- Rats
- Retroviridae
(genetics)
- Sequence Homology, Amino Acid
- Time Factors
- Treatment Outcome
- Tunica Intima
(drug effects, metabolism, pathology)
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