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Long term inhibition of neointima formation in balloon-injured rat arteries by intraluminal instillation of a matrix-targeted retroviral vector bearing a cytocidal mutant cyclin G1 construct.

Abstract
Restenosis from neointimal proliferation is a frequent complication of intracoronary stenting and catheter-based revascularization procedures. Currently, there is no known therapeutic strategy that has been sufficiently effective to warrant its widespread use. In the present study, the anti-proliferative properties of a matrix (collagen)-targeted retroviral vector bearing a mutant cyclin G1 (DNT 41-249) construct was evaluated in vitro and in vivo. In controlled one-month efficacy studies, the intraluminal instillation of the mutant cyclin G1 vector significantly inhibited neointima lesion formation in balloon-injured rat arteries without neointimal growth, associated necrosis or intense inflammatory reaction. Taken together, these data extend the potential utility of the matrix-targeted mutant cyclin G1 retroviral vector for management of vascular restenosis.
AuthorsF Xu, M F Prescott, P X Liu, Z H Chen, G Liau, E M Gordon, F L Hall
JournalInternational journal of molecular medicine (Int J Mol Med) Vol. 8 Issue 1 Pg. 19-30 (Jul 2001) ISSN: 1107-3756 [Print] Greece
PMID11408944 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CCNG1 protein, human
  • Ccng1 protein, mouse
  • Ccng1 protein, rat
  • Cyclin G
  • Cyclin G1
  • Cyclins
  • DNA, Antisense
  • DNA, Recombinant
Topics
  • 3T3 Cells
  • Amino Acid Sequence
  • Angioplasty, Balloon (adverse effects)
  • Animals
  • Carotid Arteries (chemistry, pathology)
  • Carotid Artery Injuries (etiology, genetics, prevention & control)
  • Cell Division (drug effects, genetics)
  • Cell Line
  • Cyclin G
  • Cyclin G1
  • Cyclins (administration & dosage, analysis, genetics, therapeutic use)
  • DNA, Antisense (genetics)
  • DNA, Recombinant (genetics)
  • Gene Transfer Techniques
  • Genetic Therapy (methods)
  • Genetic Vectors (administration & dosage)
  • Humans
  • Immunohistochemistry
  • Mice
  • Molecular Sequence Data
  • Muscle, Smooth, Vascular (cytology, drug effects, metabolism)
  • Mutation
  • Rats
  • Retroviridae (genetics)
  • Sequence Homology, Amino Acid
  • Time Factors
  • Treatment Outcome
  • Tunica Intima (drug effects, metabolism, pathology)

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