Vaginal
bromocriptine has proven safe and effective in treating hyperprolactinemic women. However, there has been no long-term clinical assessment regarding the influence of daily vaginal
bromocriptine administration on the ability to conceive. This article presents two cases of successful pregnancy resulting from this alternative treatment. An infertile woman with an empty sella and
hyperprolactinemia was treated with vaginal
bromocriptine because of intolerance to
oral administration.
Prolactin levels were quickly normalized and no side effects occurred. Repeated postcoital tests during treatment proved normal. Twelve months later, the patient conceived. The
therapy was discontinued during pregnancy, without complications. Although
bromocriptine treatment was not resumed after delivery, postpartum
prolactin levels were lower than before treatment and magnetic resonance imaging revealed an unchanged empty sella. Another patient with
infertility and pituitary microadenoma with intolerance to oral
dopaminergic agonists received the same treatment.
Prolactin quickly fell to within the normal range. Vaginal
bromocriptine was well tolerated and postcoital test results were not impaired.
Tumor regression occurred and 10 months later the patient conceived. Despite
bromocriptine withdrawal, no significant complications occurred during pregnancy. It can therefore be concluded that a couple's fertility does not appear to be significantly affected by the persistent local presence of
bromocriptine.