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Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar disease.

Abstract
The aim of the present study was to investigate the expression of nm23-H1 in human placenta, hydatidiform mole and choriocarcinoma cells. Nm23-H1 protein was localized in the cytotrophoblast, but not in the syncytiotrophoblast. In the hydatidiform mole cases with subsequent spontaneous remission, nm23-H1 mRNA levels were significantly lower than those in first-trimester placentas. However, its levels were elevated in the hydatidiform mole cases that progressed to persistent gestational trophoblastic disease and were comparable to those of first-trimester placentas, and they were further elevated in choriocarcinoma cells. The present data suggest an association of nm23-H1 for the proliferation activity of trophoblast, and its increased expression may influence the development of persistent trophoblastic disease.
AuthorsK Iwase, T Okamoto, R Nui, S Mizutani
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 51 Issue 4 Pg. 228-32 ( 2001) ISSN: 0378-7346 [Print] Switzerland
PMID11408732 (Publication Type: Journal Article)
CopyrightCopyright 2001 S. Karger AG, Basel
Chemical References
  • NM23 Nucleoside Diphosphate Kinases
  • RNA, Messenger
  • Transcription Factors
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • Monomeric GTP-Binding Proteins
Topics
  • Blotting, Northern
  • Choriocarcinoma (chemistry)
  • Female
  • Gestational Age
  • Humans
  • Hydatidiform Mole (chemistry, complications)
  • Immunohistochemistry
  • Monomeric GTP-Binding Proteins (analysis, genetics)
  • NM23 Nucleoside Diphosphate Kinases
  • Nucleoside-Diphosphate Kinase
  • Placenta (chemistry)
  • Pregnancy
  • RNA, Messenger (analysis)
  • Transcription Factors (analysis, genetics)
  • Trophoblastic Neoplasms (chemistry, etiology)
  • Trophoblasts (chemistry)
  • Tumor Cells, Cultured
  • Uterine Neoplasms (chemistry, complications)

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