Abstract | OBJECTIVE: To determine whether major histocompatibility complex class I chain-related gene A ( MICA) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) independently of the HLA-DRB1 shared epitope (SE). METHODS: Fifty-four Spanish families with an affected son or daughter and 211 consecutive RA patients were genotyped for HLA-DRB1, tumor necrosis factor a/b microsatellite alleles, and MICA transmembrane polymorphism. We performed a case-control comparison with the consecutive patients and an independent transmission disequilibrium test with the families. RESULTS: The frequency of the MICA 6.0 allele was significantly reduced, compared with controls, in the group of SE+ patients (odds ratio 0.39, P = 0.0005). Additionally, the haplotypes containing this allele were preferentially not transmitted to the affected offspring (9 transmitted of 33; P = 0.007), independent of the presence or absence of an SE either in the same haplotype or in the other haplotype in the progenitor. CONCLUSION: These data suggest that the MICA 6.0 allele is an independent marker of protection against RA in the SE+ group of RA patients.
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Authors | A Martinez, M Fernandez-Arquero, A Balsa, A Rubio, H Alves, D Pascual-Salcedo, E Martin-Mola, E G de la Concha |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 44
Issue 6
Pg. 1261-5
(Jun 2001)
ISSN: 0004-3591 [Print] United States |
PMID | 11407684
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Genetic Markers
- Histocompatibility Antigens Class I
- MHC class I-related chain A
- DNA
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Topics |
- Adult
- Alleles
- Arthritis, Rheumatoid
(prevention & control)
- DNA
(analysis)
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Haplotypes
(genetics)
- Histocompatibility Antigens Class I
(genetics)
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
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