Abstract | OBJECTIVE: METHODS: RESULTS: Treatment with 10 mg/kg cyclosporin A, as well as combination therapy with half dosages of cyclosporin A (5 mg/kg) plus PHL significantly inhibited both inflammation and destructive arthritis-associated changes. Significant differences in favor of combination therapy with 5 mg/kg CsA + 300 mg/kg PHL as compared to 5 mg/kg CsA alone were seen in hind paw swelling. Also, reduction of the radiographic scores was more significant in the combination therapy group. Five mg cyclosporin A or PHL alone reduced the disease markers studied to a lesser extent, and in the case of enzyme therapy this occurred at a later stage of arthritis development. CONCLUSION:
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Authors | E Rovenská, K Svík, M Stancíková, J Rovenský |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2001 May-Jun
Vol. 19
Issue 3
Pg. 303-9
ISSN: 0392-856X [Print] Italy |
PMID | 11407084
(Publication Type: Journal Article)
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Chemical References |
- Antirheumatic Agents
- Drug Combinations
- Nitrates
- Nitrites
- Phlogenzym
- Serum Albumin
- Rutin
- Cyclosporine
- Bromelains
- Collagen
- Trypsin
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Topics |
- Animals
- Antirheumatic Agents
(pharmacology)
- Arthritis, Rheumatoid
(chemically induced, drug therapy, pathology)
- Bone and Bones
(pathology)
- Bromelains
(pharmacology)
- Cattle
- Collagen
- Cyclosporine
(pharmacology)
- Drug Combinations
- Drug Therapy, Combination
- Male
- Nitrates
(blood)
- Nitrites
(blood)
- Rats
- Rats, Inbred Lew
- Rutin
(analogs & derivatives, pharmacology)
- Serum Albumin
- Trypsin
(pharmacology)
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