The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent.
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| Abstract |
Procyanidin B-2 is a compound we have identified in apple which acts as a growth-promoting factor on murine hair epithelial cells. This report describes our investigation of the hair-growing effects of 1% procyanidin B-2 tonic after sequential use for 4 months. A double-blind clinical trial was performed, involving a total of 29 subjects (procyanidin B-2, 19 men; placebo, 10 men). No adverse side effects were observed in either group. In the procyanidin B-2 group, 78.9% showed an increased mean value of hair diameter, whereas only 30.0% in the placebo group showed any increase (p < 0.02, Fisher's exact probability test). The increased ratio of hairs measuring more than 40 microm in diameter after 4 months of procyanidin B-2 treatment was significantly higher than that of the placebo controls (p < 0.05, two-sample-t-test). The increase in number of total hairs in the designated scalp area (0.25 cm(2)) of procyanidin B-2 subjects after a 4 month trial was significantly greater than that of the placebo controls (procyanidin-B-2, 3.67 +/- 4.09 (mean +/- SD)/0.25 cm(2); placebo, -2.54 +/- 4.00/0.25 cm(2); p < 0.001, two-sample t-test). Procyanidin B-2 therapy shows potential as a promising cure for male pattern baldness.
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| Authors | T Takahashi, A Kamimura, Y Yokoo, S Honda, Y Watanabe |
| Journal | Phytotherapy research : PTR (Phytother Res) Vol. 15 Issue 4 Pg. 331-6 (Jun 2001) ISSN: 0951-418X [Print] England |
| PMID | 11406858 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial) |
| Copyright | Copyright 2001 John Wiley & Sons, Ltd. |
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