Abstract | BACKGROUND: OBSERVATION: Three patients previously diagnosed as having Netherton syndrome were treated at different centers with 0.1% tacrolimus ointment twice daily. Two patients showed dramatic improvement. All patients were found to have tacrolimus blood levels within or above the established therapeutic trough range for oral tacrolimus in organ transplant recipients. None of these patients developed signs or symptoms of toxic effects of tacrolimus. CONCLUSIONS:
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Authors | A Allen, E Siegfried, R Silverman, M L Williams, P M Elias, S K Szabo, N J Korman |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 137
Issue 6
Pg. 747-50
(Jun 2001)
ISSN: 0003-987X [Print] United States |
PMID | 11405764
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Tacrolimus
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Topics |
- Administration, Cutaneous
- Child
- Child, Preschool
- Female
- Humans
- Ichthyosiform Erythroderma, Congenital
(drug therapy, metabolism)
- Immunosuppressive Agents
(administration & dosage, blood, pharmacokinetics, therapeutic use)
- Male
- Skin Absorption
- Syndrome
- Tacrolimus
(administration & dosage, blood, pharmacokinetics, therapeutic use)
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