Abstract | OBJECTIVES AND HYPOTHESIS: STUDY DESIGN: Randomized, prospective, and controlled. METHODS: Forty-one adult guinea pigs underwent either a unilateral endolymphatic duct occlusion to induce hydrops or a sham procedure. Ten weeks after induction of the hydrops, a KTP laser-assisted TSCA or a sham surgery was performed. RESULTS: Electrocochleographic thresholds to clicks and tone-bursts (2-20 kHz) did not change significantly up to 4 weeks after TSCA in hydropic ears. Cross-sectional histology confirmed the presence of hydrops and the ablation of the semicircular canals. Cochlear whole-mounts for hair cell counts showed no significant loss of outer or inner hair cells in hydropic ears treated with TSCA. CONCLUSION:
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Authors | M Adamczyk, P J Antonelli |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 111
Issue 6
Pg. 1057-62
(Jun 2001)
ISSN: 0023-852X [Print] United States |
PMID | 11404621
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Audiometry, Evoked Response
- Disease Models, Animal
- Endolymphatic Hydrops
(pathology, surgery)
- Epithelium
(pathology, surgery)
- Female
- Guinea Pigs
- Hair Cells, Auditory
(pathology)
- Laser Therapy
- Male
- Meniere Disease
(pathology, surgery)
- Prospective Studies
- Semicircular Canals
(pathology, surgery)
- Treatment Outcome
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