Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase.

Abstract

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells.

• Authors: P Cuq, C Rouquet, A Evrard, J Ciccolini, L Vian, J P Cano
• Journal: British journal of cancer (Br J Cancer) Vol. 84 Issue 12 Pg. 1677-80 (Jun 15 2001) ISSN: 0007-0920 [Print] England
• PMID: 11401323 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 Cancer Research Campaign.

Chemical References

• Antimetabolites, Antineoplastic
• Ribonucleotides
• Uridine Phosphorylase
• Fluorouracil

Topics

• Antimetabolites, Antineoplastic (pharmacology)
• Breast Neoplasms (pathology)
• Female
• Fluorouracil (pharmacology)
• Genetic Therapy
• Humans
• Ribonucleotides
• Transfection
• Tumor Cells, Cultured
• Uridine Phosphorylase (biosynthesis, genetics, metabolism)