HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Black tea extract, thearubigin fraction, counteracts the effect of tetanus toxin in mice.

Abstract
The aim of this study was to find an inactivating substance for tetanus toxin in natural foodstuff. Tetanus toxin (4 micrograms/ml) abolished indirect twitches in In vitro mouse phrenic nerve-diaphragm preparations within 2.5 hr. Hot water infusion of black tea mixed with tetanus toxin blocked the inhibitory effect of the toxin. Mixing the toxin with thearubigin fraction extracted from black tea infusion produced an identical result. Furthermore, thearubigin fraction mixed with the toxin protected against the in vivo paralytic effect of the toxin. Thearubigin fraction had no protective effect on other toxins, such as tetrodotoxin and saxitoxin. The specific binding of [125I]tetanus toxin to rat cerebrocortical synaptosomes was inhibited by mixing iodinated toxin with thearubigin fraction. These results imply that thearubigin fraction counteracts the effect of tetanus toxin by binding with toxin, and also suggest that this fraction may be able to apply for prophylaxis of tetanus.
AuthorsE Satoh, T Ishii, Y Shimizu, S Sawamura, M Nishimura
JournalExperimental biology and medicine (Maywood, N.J.) (Exp Biol Med (Maywood)) Vol. 226 Issue 6 Pg. 577-80 (Jun 2001) ISSN: 1535-3702 [Print] England
PMID11395929 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Phenols
  • Plant Extracts
  • Polyphenols
  • Tea
  • Tetanus Toxin
  • thearubigin
  • Catechin
Topics
  • Animals
  • Catechin (analogs & derivatives)
  • Chemical Fractionation
  • Female
  • Male
  • Mice
  • Phenols
  • Plant Extracts (pharmacology)
  • Polyphenols
  • Rats
  • Rats, Wistar
  • Tea (chemistry)
  • Tetanus Toxin (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: