| Abstract | PURPOSE: To analyze the efficacy and toxicity of adjuvant whole abdomen irradiation (WAI) and concomitant chemotherapy in the treatment of completely resected, high-risk gastric cancer. METHODS AND MATERIALS: Between October 1990 and September 1997, 52 patients with completely resected gastric cancer, with lymph node and/or serosal involvement, were treated. Ages were 16-78 (median, 53.5) years. Treatment was either total- or sub-total gastrectomy, followed by WAI, 2100 cGy/21 fractions plus a 2400 cGy/16 fractions boost to the tumor bed. Chemotherapy consisted of either 5-fluorouracil (5-FU) 450-500 mg/m(2) i.v. for 5 days first and 5th week or 200-300 mg/m(2) continuous infusion during irradiation. No further chemotherapy was given. RESULTS: With a minimum follow-up of 30 months and a median follow-up of 43.5 months, 25 of the 52 patients have died. Overall 5-year survival rate is 54%. Three patients sustained Grade 3-5 complications. Two patients with Grade 5 complications (malabsorption syndrome) died 31 and 56 months after the beginning of the treatment, respectively, with no evidence of recurrent tumor. For patients with involvement of the lymph nodes alone (n = 19) the 5-year survival was 69%, which was significantly better than the 36% 5-year survival observed for those patients with both serosal and lymph node involvement (n = 26, p = 0.004). CONCLUSION: Adjuvant radiochemotherapy, WAI, and concomitant 5-FU, is a feasible and a fairly well-tolerated treatment for patients with locally advanced (involvement of the lymph nodes or serosa) gastric carcinoma who undergo complete resection. The 54% overall 5-year survival compares favorably with the survival reported after surgery alone for those patients. |
| Authors | M R Baeza, O Giannini T, R Rivera S, P González, J González, E Vergara, C del Castillo, J Madrid, E Vinés
(Affiliation: Department of Radiotherapy, Instituto de Radiomedicina, IRAM, Santiago, Chile. mbaeza at rdc.cl)
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| Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 50
Issue 3
Pg. 645-50
(Jul 1 2001)
ISSN: 0360-3016 United States |
| PMID | 11395231
(Publication Type: Clinical Trial, Journal Article)
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| Chemical References |
- Antimetabolites, Antineoplastic
- Fluorouracil
|
| Topics |
- Adult
- Aged
- Antimetabolites, Antineoplastic
(adverse effects, therapeutic use)
- Chemotherapy, Adjuvant
(adverse effects)
- Dose Fractionation
- Female
- Fluorouracil
(adverse effects, therapeutic use)
- Gastrectomy
- Humans
- Lymphatic Metastasis
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Staging
- Proportional Hazards Models
- Radiotherapy, Adjuvant
(adverse effects)
- Stomach Neoplasms
(drug therapy, radiotherapy, surgery)
- Survival Rate
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