HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effects of eight polycyclic aromatic compounds on the survival and reproduction of the springtail Folsomia fimetaria L. (Collembola, isotomidae).

Abstract
The effects of eight polycyclic aromatic compounds on the survival and reproduction of the collembolan Folsomia fimetaria L. were investigated in a well-characterized Danish agricultural soil. With the exception of acridine, polycyclic aromatic hydrocarbons (PAHs) and neutral N-, S-, and O-monosubstituted analogues showed similar toxicities to soil collembolans when the results were expressed in relation to total soil concentrations (mg/kg). The estimated concentrations resulting in a 10% reduction of reproductive output (EC10 values) were based on measured initial concentrations and were for acridine 290 mg/kg, carbazole 10 mg/kg, dibenzofuran 19 mg/kg, dibenzothiophene 7.8 mg/kg, fluoranthene 37 mg/kg, fluorene 7.7 mg/kg, phenantrene 23 mg/kg, and pyrene 10 mg/kg. When the EC10 values were converted to soil pore-water concentrations, they showed a highly significant correlation (r2 = 0.71, p < 0.01) to no-observed-effect concentrations for the freshwater crustacean Daphnia magna, as estimated by a quantitative structure activity relation (QSAR) for baseline toxicity (nonpolar narcosis). Only carbazole and acridine were more than two times more toxic (4.9 and 3.1, respectively) than expected from the Daphnia QSAR data. The latter result indicates that the toxicity of the tested substances is close to that expected for compounds with nonpolar narcosis as the mode of action. However, the relatively large uncertainties in the extrapolation method prevent final conclusions from being drawn.
AuthorsL E Sverdrup, A E Kelley, P H Krogh, T Nielsen, J Jensen, J J Scott-Fordsmand, J Stenersen
JournalEnvironmental toxicology and chemistry / SETAC (Environ Toxicol Chem) Vol. 20 Issue 6 Pg. 1332-8 (Jun 2001) ISSN: 0730-7268 [Print] United States
PMID11392144 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carbazoles
  • Polycyclic Hydrocarbons, Aromatic
  • Soil Pollutants
  • Water Pollutants, Chemical
Topics
  • Animals
  • Arthropods (physiology)
  • Carbazoles (toxicity)
  • Daphnia (physiology)
  • Denmark
  • Dose-Response Relationship, Drug
  • Fertility (drug effects)
  • Kinetics
  • Larva
  • Necrosis
  • No-Observed-Adverse-Effect Level
  • Polycyclic Hydrocarbons, Aromatic (toxicity)
  • Quantitative Structure-Activity Relationship
  • Reproduction (drug effects)
  • Soil Pollutants (toxicity)
  • Survival
  • Water Pollutants, Chemical (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: