HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

One-month follow-up of patients treated by intravenous clodronate for acute pain induced by osteoporotic vertebral fracture.

Abstract
Disodium-clodronate is one of the most experimented drugs for the management of bone pain caused by vertebral fractures induced by skeletal metastases and myeloma as well as by osteoporosis. In a previous study, treatment with intravenous disodium-clodronate 300 mg/day in saline produced satisfactory relief of moderate or severe back pain in 15 patients with painful vertebral crush. The present study examines the general behavior of pain in patients suffering from vertebral crush when treated with intravenous disodium-clodronate and after discontinuation of medication. At the end of treatment, pain relief was significantly greater in patients treated with disodium-clodronate. After discontinuation of treatment the patients who had been taking disodium-clodronate for pain due to vertebral crush were generally better than those previously on acetaminophen. At the end of follow-up, no significant differences were found between the two groups. In our study, the use of disodium-clodronate was associated with a reduction in the number of days the patients experienced severe pain, which suggests that disodium-clodronate is a first-line drug in the treatment of recent vertebral crush.
AuthorsG Rovetta, G Maggiani, L Molfetta, P Monteforte
JournalDrugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 27 Issue 2 Pg. 77-81 ( 2001) ISSN: 0378-6501 [Print] Switzerland
PMID11392057 (Publication Type: Journal Article)
Chemical References
  • Analgesics, Non-Narcotic
  • Clodronic Acid
Topics
  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Analgesics, Non-Narcotic (therapeutic use)
  • Clodronic Acid (therapeutic use)
  • Female
  • Follow-Up Studies
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Osteoporosis (complications)
  • Pain (drug therapy)
  • Spinal Fractures (physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: