Effectiveness of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus.

Abstract

PURPOSE:

To evaluate the efficacy of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus.

METHODS:

Sixteen patients with restrictive strabismus resulting from trauma, retinal detachment surgery, and multiple squint surgeries were randomized to either a mitomycin group (8 patients) or a control group (8 patients). Mitomycin C (0.2 mg/mL) was applied intraoperatively for 5 minutes after release of adhesions. Range of passive ductions was scored for comparison. Postoperative follow-up ranged from 3-18 months.

RESULTS:

Compared to controls, the mitomycin C group had better range of passive ductions. There were no complications related to the cornea, intraocular pressure, uveitis, or muscle disinsertion in the mitomycin C group.

CONCLUSION:

Intraoperative application of mitomycin C (0.2 mg/mL for 5 minutes) is a safe and effective adjunct to surgery in the treatment of restrictive strabismus.

• Authors: A Mahindrakar, R Tandon, V Menon, P Sharma, S Khokhar
• Journal: Journal of pediatric ophthalmology and strabismus (J Pediatr Ophthalmol Strabismus) 2001 May-Jun Vol. 38 Issue 3 Pg. 131-5; quiz 172-3 ISSN: 0191-3913 [Print] United States
• PMID: 11386644 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antibiotics, Antineoplastic
• Mitomycin

Topics

• Adolescent
• Adult
• Antibiotics, Antineoplastic (therapeutic use)
• Chemotherapy, Adjuvant
• Child
• Double-Blind Method
• Female
• Fibroblasts (drug effects)
• Follow-Up Studies
• Humans
• Male
• Mitomycin (therapeutic use)
• Postoperative Complications (drug therapy)
• Prospective Studies
• Recurrence
• Strabismus (surgery)
• Tissue Adhesions (prevention & control)
• Treatment Outcome