Effects of prostaglandin antagonist SC-19220 on body temperature and on hyperthermic responses to prostaglandin E-1 and leukocytic pyrogen in the cat.

Abstract

Intravenous injection of SC-19220 (3-9 mg/kg) caused dose-related hypothermic responses in cats. Repeated administration of SC-19220 resulted in tolerance to its hypothermic action. During SC-19220-induced hypothermia, the hyperthermic activity of both prostaglandin E-1 and leukocytic pyrogen was reduced or abolished. Neither prostaglandin E-1 nor leukocytic pyrogen was antagonized when given shortly after recovery from SC-19220-induced hypothermia or by doses of SC-19220 which did not cause hypothermia. Although these results may indicate a role of prostaglandins in normal physiological thermoregulation, it is also possible that production of hypothermia by SC-19220 is unrelated to prostaglandin antagonism.

• Authors: W G Clark, H R Cumby
• Journal: Prostaglandins (Prostaglandins) Vol. 9 Issue 3 Pg. 361-8 (Mar 1975) ISSN: 0090-6980 [Print] United States
• PMID: 1138292 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Prostaglandin Antagonists
• Prostaglandins E
• Pyrogens

Topics

• Animals
• Body Temperature (drug effects)
• Cats
• Depression, Chemical
• Dose-Response Relationship, Drug
• Hypothermia, Induced
• Injections, Intravenous
• Prostaglandin Antagonists (administration & dosage, pharmacology)
• Prostaglandins E (pharmacology)
• Pyrogens
• Stimulation, Chemical
• Time Factors