Abstract | PURPOSE: To evaluate the outcomes of patients with chronic noninfectious uveitis unresponsive to conventional antiinflammatory therapy who were treated with methotrexate. DESIGN: Retrospective noncomparative interventional case series. PARTICIPANTS: All patients with chronic noninfectious uveitis treated with methotrexate at a single institution from 1985 to 1999. METHODS: Charts of patients seen on the Ocular Immunology & Uveitis Service at the Massachusetts Eye & Ear Infirmary were reviewed. Patients with chronic uveitis of noninfectious origin treated with methotrexate were included in the study. MAIN OUTCOME MEASURES: RESULTS: A total of 160 patients met the inclusion criteria. Control of inflammation was achieved in 76.2% of patients. Steroid-sparing effect was achieved in 56% of patients. Visual acuity was maintained or improved in 90% of patients. Side effects requiring discontinuation of medication occurred in 18% of patients. Potentially serious adverse reactions occurred in only 8.1% of patients. There was neither long-term morbidity nor mortality caused by methotrexate. CONCLUSIONS:
|
Authors | C M Samson, N Waheed, S Baltatzis, C S Foster |
Journal | Ophthalmology
(Ophthalmology)
Vol. 108
Issue 6
Pg. 1134-9
(Jun 2001)
ISSN: 0161-6420 [Print] United States |
PMID | 11382642
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Immunosuppressive Agents
- Methotrexate
|
Topics |
- Adolescent
- Adult
- Aged
- Chronic Disease
- Drug Evaluation
- Female
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Methotrexate
(therapeutic use)
- Middle Aged
- Retrospective Studies
- Safety
- Uveitis
(drug therapy)
- Visual Acuity
|