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Methotrexate therapy for chronic noninfectious uveitis: analysis of a case series of 160 patients.

AbstractPURPOSE:
To evaluate the outcomes of patients with chronic noninfectious uveitis unresponsive to conventional antiinflammatory therapy who were treated with methotrexate.
DESIGN:
Retrospective noncomparative interventional case series.
PARTICIPANTS:
All patients with chronic noninfectious uveitis treated with methotrexate at a single institution from 1985 to 1999.
METHODS:
Charts of patients seen on the Ocular Immunology & Uveitis Service at the Massachusetts Eye & Ear Infirmary were reviewed. Patients with chronic uveitis of noninfectious origin treated with methotrexate were included in the study.
MAIN OUTCOME MEASURES:
Control of inflammation, steroid-sparing effect, visual acuity, adverse reactions.
RESULTS:
A total of 160 patients met the inclusion criteria. Control of inflammation was achieved in 76.2% of patients. Steroid-sparing effect was achieved in 56% of patients. Visual acuity was maintained or improved in 90% of patients. Side effects requiring discontinuation of medication occurred in 18% of patients. Potentially serious adverse reactions occurred in only 8.1% of patients. There was neither long-term morbidity nor mortality caused by methotrexate.
CONCLUSIONS:
Methotrexate is effective in the treatment of chronic noninfectious uveitis that fails to respond to conventional steroid treatment. It is an effective steroid-sparing immunomodulator, is a safe medication, and is well tolerated.
AuthorsC M Samson, N Waheed, S Baltatzis, C S Foster
JournalOphthalmology (Ophthalmology) Vol. 108 Issue 6 Pg. 1134-9 (Jun 2001) ISSN: 0161-6420 [Print] United States
PMID11382642 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Methotrexate
Topics
  • Adolescent
  • Adult
  • Aged
  • Chronic Disease
  • Drug Evaluation
  • Female
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Methotrexate (therapeutic use)
  • Middle Aged
  • Retrospective Studies
  • Safety
  • Uveitis (drug therapy)
  • Visual Acuity

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