Abstract | PURPOSE: METHODS: Effects of AWD 140-190 were studied in amygdala kindled rats after oral and intraperitoneal administration. In addition, the effect on kindling development was evaluated. In all experiments, behavioral changes in the rats in response to AWD 140-190 were monitored closely. RESULTS:
AWD 140-190 exerted potent anticonvulsant activity against focal seizures. After intraperitoneal and oral administration in fully kindled rats, the substance dose-dependently increased the threshold for induction of afterdischarges starting at 15 mg/kg. AWD 140-190 only weakly influenced the seizure severity of the animals after stimulation at the elevated afterdischarge threshold current. No adverse effects were observed up to 30 mg/kg after intraperitoneal and oral administration in the open field and in the rotarod test. No differences were found between kindled and nonkindled rats when comparing neurotoxicity of AWD 140-190. Prolonged treatment with AWD 140-190 during kindling acquisition did not prevent kindling, but significantly retarded the development of fully kindled seizures during the treatment. CONCLUSIONS:
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Authors | C Tober, W Löscher, D Hönack, R Bartsch |
Journal | Epilepsia
(Epilepsia)
Vol. 42
Issue 5
Pg. 590-9
(May 2001)
ISSN: 0013-9580 [Print] United States |
PMID | 11380565
(Publication Type: Journal Article)
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Chemical References |
- AWD 140-190
- Anticonvulsants
- Morpholines
- Proline
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Topics |
- Administration, Oral
- Amygdala
(physiology)
- Animals
- Anticonvulsants
(administration & dosage, pharmacology, therapeutic use)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Electric Stimulation
- Epilepsies, Partial
(drug therapy, etiology)
- Female
- Humans
- Injections, Intraperitoneal
- Kindling, Neurologic
(drug effects, physiology)
- Morpholines
(administration & dosage, pharmacology, therapeutic use)
- Proline
(administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
- Rats
- Rats, Wistar
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