HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hyperthermic isolated limb perfusion for extremity sarcomas.

AbstractBACKGROUND:
The treatment options available for extremity sarcomas are amputation or limb-sparing surgery with radiation, which may incur significant morbidity and body disfigurement. Hyperthermic isolated limb perfusion (HILP) may be an attractive option in extremity sarcomas for unresectable lesions to preserve limb function and maintain quality of life.
METHODS:
We report the outcomes of 5 patients who underwent HILP for unresectable primary or recurrent extremity sarcomas from 1994 to 2000 at our institution.
RESULTS:
All patients had initial complete clinical responses to HILP, and the limb was salvaged in 4 of the 5 patients. Complications included chronic lymphedema, neuropathic pain, and prolonged wound healing.
CONCLUSIONS:
HILP with melphalan is a safe and effective treatment option for selected patients with locally advanced and unresectable extremity sarcomas. The response rates are high, with limb salvage occurring in most patients. Further studies of larger groups of patients are warranted.
AuthorsC J Kim, C Puleo, G D Letson, D Reintgen
JournalCancer control : journal of the Moffitt Cancer Center (Cancer Control) 2001 May-Jun Vol. 8 Issue 3 Pg. 269-73 ISSN: 1073-2748 [Print] United States
PMID11378653 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Alkylating
  • Melphalan
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents, Alkylating (administration & dosage)
  • Bone Neoplasms (drug therapy, mortality)
  • Chemotherapy, Cancer, Regional Perfusion
  • Female
  • Humans
  • Hyperthermia, Induced
  • Leg
  • Male
  • Melphalan (administration & dosage)
  • Middle Aged
  • Retrospective Studies
  • Sarcoma (drug therapy, mortality)
  • Soft Tissue Neoplasms (drug therapy, mortality)
  • Survival Rate

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: