Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma.

Abstract

A 56-year-old woman was treated with combination chemotherapy and radiation therapy for peripheral T-cell lymphoma. Following complete remission for a period of 6 months, she returned again with marked leukocytosis. Leukemic cells were characterized by scanty cytoplasm with fine azurophilic granules, and were highly positive for myeloperoxidase and sudan black-B. Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens (CD13, CD33), and natural killer (NK) cell antigen (CD56), but negative for T-cell antigens (CD2, CD5, CD7), B-cell antigens (CD19, CD20), CD34, and HLA-DR. The case was diagnosed as secondary myeloid/NK cell acute leukemia following non-Hodgkin's lymphoma. Despite aggressive chemotherapy against leukemia, she died of multiorgan failure 7 months following onset of leukemia. We present, to the best of our knowledge, the first published report of what seems to be a secondary myeloid/NK cell acute leukemia following T-cell lymphoma.

• Authors: J J Lee, H J Kim, I J Chung, M R Park, D W Ryang, C Choi
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 41 Issue 3-4 Pg. 457-60 (Apr 2001) ISSN: 1042-8194 [Print] United States
• PMID: 11378563 (Publication Type: Case Reports, Journal Article)

Topics

• Acute Disease
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Cytogenetic Analysis
• Fatal Outcome
• Female
• Humans
• Immunophenotyping
• Killer Cells, Natural (chemistry)
• Leukemia, Myeloid (diagnosis, pathology)
• Lymphoma, T-Cell (drug therapy, pathology, radiotherapy)
• Middle Aged
• Neoplasms, Second Primary (diagnosis, pathology)