Developmentally regulated serotonin 5-HT2B receptors.

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) binds to numerous cognate receptors to initiate its biological effects. In this review, we have focused on the 5-HT2B receptor to address how signaling and expression of this receptor is specifically implicated in embryonic development and adult health and disease. Transduction of the 5-HT2B signaling is complex, including phospholipase C and A2 stimulation, cGMP production and a mitogenic signal that integrates the tyrosine kinase-signaling pathway. Furthermore, 5-HT, through the 5-HT2B receptors, has the ability to control serotonergic differentiation of committed neuron-like cells. In addition, 5-HT2B receptors are actively involved in the transient action of 5-HT during embryonic morphogenesis. Our recent data presented the first genetic evidence that 5-HT via 5-HT2B receptors regulates cardiac embryonic development and adult functions and suggested that this receptor subtype may be involved in other physiopathological situations. In particular, 5-HT-dependent molecular mechanisms may be involved in embryonic development and postnatal maturation of the enteric nervous system. Also, the involvement of the 5-HT2B receptor in the vascular growth often observed in hypertension is likely. These probably result from reactivation of developmentally regulated receptors in pathological situations. Finally, embryonic functions of 5-HT2 receptors observed in Drosophila gastrulation suggest evolutionary conserved mechanisms.

• Authors: C G Nebigil, N Etienne, B Schaerlinger, P Hickel, J M Launay, L Maroteaux
• Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (Int J Dev Neurosci) Vol. 19 Issue 4 Pg. 365-72 (Jul 2001) ISSN: 0736-5748 [Print] United States
• PMID: 11378296 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Fetal Proteins
• Nerve Tissue Proteins
• Receptor, Serotonin, 5-HT2B
• Receptors, Serotonin
• Serotonin
• Guanosine Triphosphate
• Protein Kinase C
• Type C Phospholipases
• Calcium

Topics

• Animals
• Calcium (physiology)
• Cell Differentiation
• Drosophila melanogaster (embryology, genetics)
• Embryonic and Fetal Development
• Enteric Nervous System (embryology, growth & development)
• Evolution, Molecular
• Fetal Heart (growth & development)
• Fetal Proteins (biosynthesis, genetics, physiology)
• Gastrula
• Gene Expression Regulation, Developmental
• Guanosine Triphosphate (physiology)
• Humans
• Hypertension (genetics, metabolism)
• MAP Kinase Signaling System (physiology)
• Mammals (physiology)
• Mice
• Mice, Knockout
• Morphogenesis
• Nerve Tissue Proteins (biosynthesis, genetics, physiology)
• Protein Kinase C (physiology)
• Receptor, Serotonin, 5-HT2B
• Receptors, Serotonin (biosynthesis, genetics, physiology)
• Serotonin (physiology)
• Signal Transduction
• Species Specificity
• Type C Phospholipases (physiology)