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Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide.

Abstract
In the present study, a new microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide technique has been developed. The results show that microwave irradiation can dehydrate penicillin G sulfoxide from a water content of 14-26 to below 0.5% in 40-60 min in N2 or air. After washing with ethyl acetate to remove impurities and residual water, the penicillin G sulfoxide can be used to synthesize cephalosporanic acid. The recovery of cephalosporanic acid was equal to and the purity of cephalosporanic acid was higher by 2% than that of the current dehydration technique. FTIR spectroscopy was used to study the process of microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide.
AuthorsX Pan, H Liu, Z An, J Wang, G Niu
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 220 Issue 1-2 Pg. 33-41 (Jun 04 2001) ISSN: 0378-5173 [Print] Netherlands
PMID11376965 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • penicillin G sulfoxide
  • Penicillin G
Topics
  • Chemistry, Pharmaceutical (methods)
  • Chromatography, High Pressure Liquid
  • Microwaves
  • Penicillin G (analogs & derivatives, isolation & purification)
  • Spectroscopy, Fourier Transform Infrared

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