Immunohistochemical study on proliferative activity of experimental cholesteatoma.

Abstract

In this study, we induced canal ligation cholesteatoma using Mongolian gerbils and investigated the hyperproliferative nature of canal ligation cholesteatoma by using an immunohistochemical technique with proliferation markers (cytokeratin 13/16, PCNA, EGFR, thrombomodulin). Canal ligation cholesteatoma using Mongolian gerbils had a hyperproliferative character in the suprabasal cell layer similar to human cholesteatomas. This result will provide a good morphological basis for future cholesteatoma animal research concerning the pathogenesis of cholesteatoma.

• Authors: K Park, H J Park, Y M Chun
• Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 258 Issue 3 Pg. 101-5 (Mar 2001) ISSN: 0937-4477 [Print] Germany
• PMID: 11374247 (Publication Type: Journal Article)

Chemical References

• Proliferating Cell Nuclear Antigen
• Thrombomodulin
• Keratins
• ErbB Receptors

Topics

• Animals
• Cell Differentiation (physiology)
• Cell Division (physiology)
• Cholesteatoma, Middle Ear (pathology)
• Ear Canal (pathology)
• Epithelium (pathology)
• ErbB Receptors (analysis)
• Guinea Pigs
• Immunoenzyme Techniques
• Keratins (analysis)
• Proliferating Cell Nuclear Antigen (analysis)
• Thrombomodulin (analysis)