[Diagnostic efficacy of glutamic acid decarboxylase antibody and islet cell antibody in type I diabetes mellitus].
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| Abstract | OBJECTIVE: To investigate the diagnostic efficacy of glutamic acid decarboxylase antibody (GAD65-Ab) and islet cell antibody (ICA) in type I diabetes mellitus. METHODS: 104 cases of type I diabetes mellitus and 102 normal controls were recruited, GAD65-Ab was determined with radioligand assay and ICA with ELISA. The diagnostic efficacy of GAD65-Ab and ICA was analysed by receiver-operating characteristic (ROC) curve with sensitivity, specificity and curve area. RESULTS: (1) The optimal cut-off point of GAD65-Ab was at 0.30, while that of ICA was at 0.45. The area under the curve of GAD65-Ab and ICA were 0.835 and 0.715 respectively. Compared with 0.5, the area under curve of GAD65-Ab and ICA was higher (P < 0.0001). The area under curve of GAD65-Ab was higher than that of ICA(P < 0.01). (2) In type I diabetes mellitus patients, the positivity of GAD65-Ab was not correlated to the age of onset and duration of the disease, while the positivity of ICA was correlated to the age of onset and duration. CONCLUSION: Type I diabetes mellitus can be diagnosed with GAD65-Ab and ICA. The diagnostic efficacy of GAD65-Ab is higher than that of ICA. In patients of type I diabetes mellitus with adult-onset and duration more than one year, the diagnostic efficacy of GAD65-Ab is higher than that of ICA, while in patients of type I diabetes mellitus with adolescent-onset and duration less than one year, the diagnostic efficacy of ICA is higher than that of GAD65-Ab.
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| Authors | L Ouyang, J Wang, X Zhu |
| Journal | Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 39 Issue 10 Pg. 674-6 (Oct 2000) ISSN: 0578-1426 [Print] China |
| PMID | 11374174 (Publication Type: English Abstract, Journal Article) |
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