[Unrelated or sibling donor allogeneic bone marrow transplantation for myelodysplastic syndrome].

Abstract

OBJECTIVE:

To study on allogeneic bone marrow transplantation (BMT) with unrelated donor or sibling donor for myelodysplastic syndrome-refractory anemia and myelodysplastic syndrome-refractory anemia with excess blasts in transformation patients.

METHODS:

Two male patients received chemotherapy regimen of busulfan-cyclophosphamide before allogeneic BMT. Mycophenolate mofetil combined with cyclosporin A and methotrexate was used for prevention of acute graft-versus-host disease after transplantation. Low dose heparin and lipo prostaglandin E1 were used in prophylactic regimen for hepatic veno-occlusive disease.

RESULTS:

Neutrophil count began to be higher than 0.5 x 10(9)/L on 21st and 17th days after BMT in the two patients. Disease-free survival in the two patients was 10 months and 3.5 months respectively.

CONCLUSION:

Allogeneic bone marrow transplantation with unrelated or sibling donor is an effective therapy for patients with MDS.

• Authors: H Huang, M Lin, H Meng
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 39 Issue 10 Pg. 664-6 (Oct 2000) ISSN: 0578-1426 [Print] China
• PMID: 11374171 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Bone Marrow Transplantation (methods)
• Female
• Humans
• Male
• Myelodysplastic Syndromes (therapy)
• Sibling Relations
• Tissue Donors