Gentamicin and gentamicin C1 in the treatment of complicated urinary tract infections: comparative study of efficacy, tolerance, and pharmacokinetics.

Abstract

The clinical efficacy, patient tolerance, and pharmacokinetics of gentamicin and the single component gentamicin C(1) were studied after single and multiple doses in elderly male patients. Patient tolerance was extremely good at the dose levels used. There was some evidence of renal function impairment due to repeated intramuscular doses of gentamicin, but not gentamicin C(1). The antibiotics were equally effective against the organisms present in the urine of these patients. The pharmacokinetics of the two antibiotic forms were similar, although gentamicin C(1) appeared to have a larger distribution space.

• Authors: A Mosegaard, P G Welling, P O Madsen
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 7 Issue 3 Pg. 328-32 (Mar 1975) ISSN: 0066-4804 [Print] United States
• PMID: 1137386 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Gentamicins

Topics

• Aged
• Gentamicins (adverse effects, analogs & derivatives, therapeutic use)
• Humans
• Kinetics
• Male
• Urinary Tract Infections (drug therapy)